TRACE ELEMENTS IN MEDICINE (MOSCOW)
2015. 16(1): 48-51
ORIGINAL PAPERS

INFLUENCE OF STANDARDIZED MINERAL «BISCHOFITE» ON ORGANOGENESIS PROCESSES REGISTERED IN THE ANTENATAL PERIOD OF FETAL DEVELOPMENT

T.M. Bundikova, L.I. Bugaeva, A.A. Spasov, A.A. Ozerov, T.V. Tekutova

Volgograd State Medical University, Research Institute of Pharmacology, Pavshikh Bortsov sq. 1, Volgograd, 400131, Russia.

DOI: 10.19112/2413-6174-2015-16-1-48-51 

ABSTRACT. The results of studies conducted over the past decades indicated the significance of magnesium in maintaining reproductive health and regulation of female reproductive functions both in normal and pathological states (Lebedeva et al., 2010; Bugaeva et al., 2011). Magnesium salts reduce neuronal excitability and slow neuromuscular transmission, normalize many enzymatic reactions. When used in medical practice, magnesium sulfate may change alkali balance, provoke CNS disorders, while magnesium chloride has not such side effects (Spasov et al., 2007а; Lebedeva et al., 2010). This paper is devoted to a study on standardized bishofite (VFS 42-2950-97) with specific gravity of 1.268 g/l and the content of magnesium hydrochloride in the dry residue 96–97%. The experiments were performed on 60 adult rats of both sexes, weighing 195–220 g. Three groups of pregnant rats has been formed: the 1st group was the control, the 2nd and 3rd groups were treated by standardized mineral bishofite from 6 to 16 days of pregnancy orally with the doses of 0.01 ml/kg (the therapeutically effective dose) and 0.1 ml/kg (i.e., 10 times as much as the effective dose). The control (1st group) received intragastrically distilled water, equal to that used for bishofite dissolving, in dosage of 1 ml per 100 g. There was registered the absence of damaging effect of bishofite in the dose of 0.01 ml/kg on fertility and embryonic development in the rats. In the dosage of 0.1 ml/kg, the bishofite also did not impair organogenesis processes in pregnant rats, but a decrease in fertility, body mass, craniocaudal size of fetuses and number of ossificated skeleton points in sternum and limbs was recorded.

KEYWORDS: bishofit, magnesium, rats, prenatal development.