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COMPARATIVE ASSESSMENT OF BIOELEMENT CONTENT IN HAIR IN CHILDREN AGED 7-10 YEARS OLD – RESIDENTS OF THE ARCTIC AND SUBARCTIC

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The northern regions of the Arctic (Yamalo-Nenets Autonomous Okrug, capital Salekhard – Yamalo-Nenets Autonomous Okrug) and the Subarctic (Khanty-Mansiysk – Khanty-Mansiysk Autonomous Okrug), in addition to their vital economic importance (oil and gas production), also play a key military-political role in the development of the Northern Sea Route and the protection of the Russian Federation's Arctic borders. Currently, Russia's priority is national security, which will be guaranteed in the near future by a healthy future generation. The development of acclimatization-related elemental deficiencies as a result of prolonged exposure to low temperatures has been proven. This primarily concerns Ca, which is involved in cold adaptation, and trace elements with antioxidant activity: Mg, Zn, Cu, and Se.

Objective: To study the calcium, magnesium, zinc, copper, and selenium content in the hair of primary school children living in the Yamalo-Nenets and Khanty-Mansi Autonomous Okrugs. 

Material and methods. A total of 100 primary school children (ages 7–10) were examined, 50 each from Salekhard and Khanty-Mansiysk. Using the ISM-MS method, concentrations of Ca, Mg, Zn, Cu, and Se were determined in hair samples from the children at the Central Biomedical Institute (Moscow). 

Results. Median levels of these elements in the bio substrate were within physiologically adequate limits, but closer to the lower limit, with significantly lower levels in the Arctic group: Ca (p=0,002), Mg (p=0,035), Cu (p=0,032), Zn – 1,2 times lower, Se – 1,1 times lower than in the Subarctic group.

Conclusion. Increasing the levels of Ca, Mg, Zn, Cu, and Se in the diet, combined with their administration as a vitamin-mineral complexes, represents the most effective prevention of metabolic disorders associated with their deficiency.  

KEYWORDS: Arctic, Subarctic, primary school students, calcium, magnesium, zinc, copper, selenium. 

For citation: Fomicheva T.P. Comparative assessment of bioelement content in hair in children aged 7-10 years old – residents of the arctic and subarctic. Trace elemets in medicine. 2026;27(3):50−58. DOI: 10.19112/2413-6174-2026-27-3-50-58 

REFERENCES
Gaikov M.O. Participation of bioelements in the adaptation of health workers to unfavorable factors of high latitudes. Microelements in Medicine. 2025; 26 (4): 55–62; https://doi.org/10.19112/2413-6174-2025-26-4-55-62. (In Russian). Golovacheva V.A., Tabeeva G.R. Neurotic disorders, headache, stress: experience of managing a comorbid patient and the role of magnesium preparations. Medical Council. 2021; 2: 94–100; https://doi.org/10.21518/2079-701X-2021-2-94-100. (In Russian). Golubkina N.A., Korchina T.Ya., Merkulova N.N., Pesin S.A. Selenium status of the Khanty-Mansi Autonomous Okrug. Microelements in medicine. 2005; 6(1): 2–7. (In Russian). Gorbachev A.L. Biogeochemical characteristics of the northern regions of Russia. Collection of papers dedicated to the 90th anniversary of the founding of Magadan "Man in the North: systemic mechanisms of adaptation". Magadan: Express-poligrafiya, 2019; 3: 70. (In Russian). Gorbachev A.L. Microelement status and health of residents of northern regions: a scientific review. Human Ecology. 2025; 32(4): 225–238; https://doi.org/10.17816/humeco646046 EDN: ILROFE. (In Russian). Gromova O.A., Torshin I.Yu. Magnesium and “diseases of civilization”: a practical guide. Moscow: GEOTAR-Media; 2018: 799 p. (In Russian). Efimova N.V., Mylnikova I.V. Characteristics of physical development of children of the Yamalo-Nenets Autonomous Okrug. Human ecology. 2017; 10: 71–75. (In Russian). Zavyalov D.A., Samarov A.S. The influence of climatic factors and conditions of the Far North on the physical development of children. Proceedings of the V International Scientific and Practical Conference "Educational Technologies in the Modern Educational and Upbringing Space", Petrozavodsk, December 16. 2020: 8–13. (In Russian). Kalyuzhny E.A. Morphofunctional state and adaptive capabilities of students of educational institutions in modern conditions: monograph. Arzamas: Arzamas branch of UNN. 2020: 328 p. (In Russian). Korchin V.I., Korchina T.Ya., Bikbulatova L.N., Ternikova E.M., Lapenko V.V. The influence of climatic and geographic factors of the Yamalo-Nenets Autonomous Okrug on population health. Journal of Medical and Biological Research. 2021; 1: 77–88; https://doi.org/10.37482/2687-1491-Z046. (In Russian). Korchina T.Ya., Minyailo L.A., Korchin V.I., Safarova O.A. Comparative indicators of iron and manganese content in hair of women from the northern region with different drinking water treatment. Human ecology. 2018; 4: 6–11. (In Russian). Korchina T.Ya., Korchin V.I. Comparative analysis of the chemical composition of natural waters of the Khanty-Mansiysk and Yamalo-Nenets Autonomous Okrugs. Population Health and Environment. 2022; 1: 27–31; https://doi.org/10.35627/2219- 5238/2022-30-1-43-47. (In Russian). Korchina T.Ya., Kirichuk A.A., Sharifov M.I. Ecological and physiological assessment of calcium and magnesium status of residents of the cities of Khanty-Mansiysk and Salekhard. Russian Journal of Environmental and Rehabilitation Medicine. 2024; 4: 46–53. (In Russian). Krutikhina S.B., Gorelov A.V., Yablokova E.A., Polotnyanko E.Yu. The role of calcium, vitamins D and K in the formation of musculoskeletal health in children. Pharmateka. 2019; 26(2): 83–88. https://dx.doi.org/10.18565/pharmateca.2019.2.83-88. (In Russian). Lapenko V.V., Bikbulatova L.N., Ternikova E.M. Ecological and physiological assessment of the chemical composition of tap water in the cities of Khanty-Mansiysk and Salekhard. Ulyanovsk Medical and Biological Journal. 2020; 3: 159–167; https://doi.org/10.34014/2227-1848-2020-3-159-167. (In Russian). Lugovaya E.A., Stepanova E.M., Vinogradova I.A., Zhukova O.V., Matveeva Yu.P. Assessment and optimization of the elemental status of the body – prospects for personalized medicine. Moscow: LENAND. 2026: 200. (In Russian). Minyailo L.A., Korchina T.Ya., Korchin V.I. Correlation links between the content of chemical elements in the hair of residents of Nyagan and Nefteyugansk and their concentration in drinking water. Medical Science and Education of the Urals. 2019; 3: 19–24. (In Russian). Morozova O.S., Dedyukhina O.E., Sergeeva T.B., Shashkova E.Yu., Shchegoleva L.S. The state of cellular immunity in women of the Yamalo-Nenets Autonomous Okrug of the Russian Federation. Human Ecology. 2026; 33(2): 131–139; https://doi.org/10.17816/humeco692191 L. (In Russian). Risnik D.V., Barabash A.L. Relationship between morbidity of the population of the Tambov region and the mineral composition of drinking artesian waters. Microelements in Medicine. 2019; 20(2): 28–38; https://doi.org/10.19112/2413-6174-2019- 20-2-28-38. (In Russian). Skalny A.V., Skalnaya M.G., Kirichuk A.A., Tinkov A.A. Medical Elementology. Moscow: RUDN University. 2021: 199. (In Russian). Suplotova L.A., Sharofilova N.V., Nekrasova M.R., Gubina V.V., Luzina I.G., Kretinina L.N., Osadchenko G.A., Khramova E.B., Turovinina E.F. Monitoring of the iodine deficiency prevention program in Western Siberia. Problems of Endocrinology. 2002; 48(6): 13–16. https://doi.org/10.14341/probl11706. (In Russian). Suplotova L.A., Makarova O.B., Sharukho G.V., Kovalzhina L.S. The role of nutrition in the prevention and correction of iodine deficiency states in endemic areas. Nutrition Issues. 2018; 87(5): 27–36; https://doi.org/10.24411/0042-8833-2018-10050. (In Russian).
Chebargina M.A., Senkevich O.A., Kovalsky Yu.G. Factor analysis of the influence of micronutrient status on the physical and cognitive development of primary school children. Journal of Siberian Medical Sciences. 2023; 7(2): 29–41; https://doi.org/10.31549/2542-1174-2023-7-2-29-41. (In Russian). Shikh E.V., Makhova A.A., Shikh N.V., Nikitin E.Yu. Social jet lag: possibilities of micronutrient support. Nutrition Issues. 2022; 91(3): 85–95; https://doi.org/10.33029/0042-8833-2022-91-3-85-95. (In Russian). Shcherbakova A.S. The climate factor in the life of northerners: objective data and subjective assessments. Human Ecology. 2019; 7: 24–32; https://doi.org/10.33396/1728-0869-2019-7-24-32. (In Russian). Yakhiyaev M.A., Salikhov Sh.K., Abdulkadyrova S.O., Asel'derova A.Sh., Surkhaeva Z.Z., Kazanbieva P.D., Ibragimova E.I., Alieva D.Z., Adilova M.A., Abusueva B.A., Abusueva Z.S. Magnesium content in the environment and the incidence of arterial hypertension in the population. Hygiene and Sanitation. 2019; 98(5): 494–497; http://dx.doi.org/10.18821/0016-9900-2019-98-5- 494-497. (In Russian). Al Alawi A.M., Majoni S.W., Falhammar H. Magnesium and human health: perspectives and research directions. Int. J. Endocrinol. 2018; 16: 9041694; http://dx.doi.org/10.1155/2018/9041694. Cai Y.D., Liu X., Chow G.K., Hidalgo S., Jackson K.C., Vasquez C.D., Gao Z.Y., Lam V.H., Tabuloc C.A., Zheng H., Zhao C., Chiu J.C. Alternative splicing of Clock transcript mediates the response of circadian clocks to temperature changes. Proc Natl Acad Sci USA. 2024; 121(50): 2410680121; https://doi.org/10.1073/pnas.2410680121. Choi S., Liu X., Pan Z. Zinc deficiency and cellular oxidative stress: prognostic implications in cardiovascular diseases. Acta Pharmacol. 2018; 39(7): 1120–1132; https://doi.org/10.1038/aps.2018.25. DiNicolantonio J.J., O’Keefe J.H., Wilson W. Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis. Open Heart. 2018; 5. Article ID e000668; https://doi.org/10.1136/openhrt-2017-000668. Fiorentini D., Cappadone C., Farruggia G., Prata C. Magnesium: biochemistry, nutrition, detection, and social impact of diseases linked to its deficiency. Nutrients. 2021; 13(4): 1136; https://doi.org/10.3390/nu13041136. Fischer V., Haffner-Luntzer M., Amling M., Ignatius A.1. Calcium and vitamin D in bone fracture healing and post-traumatic bone turnover. Eur Cell Mater. 2018; 22(35): 365–385; https://doi.org/10.22203/eCM.v035a25. GBD 2021 US Burden of Disease Collaborators. The burden of diseases, injuries, and risk factors by state in the USA, 1990– 2021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet. 2024; 404(10469): 2314–2340; https://doi.org/10.1016/S0140-6736 (24)01446-6. Malyavskaya S.I., Kostrova G.N., Kudryavtsev A.V., Lebedev A. Low vitamin D levels among children and adolescents in an Arctic population. Scandinavian Journal of Public Health. 2023; 51(7): 1003–1008; https://doi.org/10.1177/14034948221092287. Michlska-Mosiej M., Socha K., Soroczynska J., Karpinska E., Tazarczyk K.B., Borauska M.Y. Selenium, Zink, Copper, and Total Antioxidant Status in the Serum of Patients with Chronic Tonsillitis Biol. Trace Elem. Res. 2016; 173(1): 30–34; https://doi.org/10.1007/s12011-016-0634-2. Mohammed S. Razzaque Magnesium: Are We Consuming Enough? Nutrients. 2018; 10(12): 1863; https://doi.org/10.3390/nu10121863. Olloquequi J., Cornejo-Cordova E., Verdaguer E., Soriano F.X., Binvignat O., Auladell C., Camins A. Excitotoxicity in the pathogenesis of neurological and psychiatric disorders: therapeutic implications. J. Psychopharmacol. 2018; 32: 265–275; https://doi.org/10.1177/0269881118754680. Reddy P., Edwards L.R. Magnesium supplementation in vitamin D deficiency. Am J Ther. 2019; 26(1): 124–132; https://doi.org/10.1097/mjt.0000000000000538. Skalnaya M.G., Skalny A.V. Essential trace elements in human health: a physician’s view. Publishing House of Tomsk State University. Tomsk. 2018: 224. Stroebel D., Casado M., Paoletti P. Triheteromeric NMDA receptors: from structure to synaptic physiology. Curr. Opin. Physiol. 2018; 2: 1–12; https://doi.org/10.1016/j.cophys.2017.12.004. Wołonciej M., Milewska E., Roszkowska-Jakimiec W. Trace elements an activator of antioxidant enzymes. Postepy Higieny i Medycyny. Doswiadczalnej (Online). 2016; 31(70): 1483–1498; https://doi.org/10.5604/17322693.1229074. Yao P., Bennett D., Mafham M., Lin X., Chen Z., Armitage J., Clarke R. Vitamin D and calcium for the prevention of fracture: a systematic review and meta-analysis. JAMA Netw Open. 2019; 2: e1917789; https: //doi.org/10.1001/jamanetworkopen.2019.17789.

Information about the author:
Tatiana P. Fomicheva – Post-graduate Student of the Department of Medical and Biological Chemistry
E-mail: n35f92@mail.ru; http://orcid.org/0009-0007-5835-0387; SPIN: 8815-1316

Conflict of interest
The author declares no obviousand potential conflicts of interest related to the publication of this article.