ABSTRACT. Objective – comparative analysis of both toxic and essential metals in hair of women living in Kostroma and Ivanovo.
Materials and methods. A total of 180 adult women living in Kostroma (n = 80) and Ivanovo (n = 100) were examined. Mean age of the examinees was 40±13 and 42±14 years old. Assessment of hair metal levels was performed using inductively-coupled plasma mass-spectrometry (ICP-MS).
Results. The obtained data show high similarity of patterns of both toxic and essential metal accumulation in hair of women from Kostroma and Ivanovo. At the same time, hair iron and manganese levels in hair of examinees from Kostroma exceeded those from Ivanovo by 35% and 17%, respectively. In turn, hair tin and copper content in women from Ivanovo were higher by 60% and 11%. When compared to the Russian reference values of metal content in hair, high frequency of excessive accumulation of aluminum (Ivanovo – 22,5%), nickel (Kostroma – 20,5%), chromium (Kostroma – 28,2%, Ivanovo – 29,5%), iron (Kostroma – 28,2%), selenium (Kostroma – 33,3%, Ivanovo – 39,5%), vanadium (Kostroma – 30,8%, Ivanovo – 29,5%), and especially manganese (Kostroma – 41,0%, Ivanovo – 20,2%) was observed. Noteworthy, both women from Kostroma (56,4%) and Ivanovo (39,5%) were characterized by high incidence of low levels of copper in hair.
Conclusions. The results of the study show high risk of adverse health effects of excessive accumulation of manganese, chromium, and nickel, along with low intake of copper in women living in Kostroma and Ivanovo. Given the role of metal overload in development of multiple diseases, further research and monitoring of environmental metal pollution is required for prevention of its adverse effect on human health.
KEYWORDS: metals, manganese, nickel, iron, health.
For citation: Skalny A.A., Korobeinikova T.V., Mazaletskaya A.L., Flerova E.A., Grabeklis A.R., Rylina E.V., Tinkov A.A. Comparative analysis of toxic and essential metal and metalloid levels in hair of inhabitants from Kostroma and Ivanovo. Trace elemets in medicine. 2025;26(3):16−25. DOI: 10.19112/2413-6174-2025-26-3-16-25
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Information about the authors:
Andrey A. Skalny – Ph.D. (Med.), Associate Professor of the Department of Medical Elementology for Bioelementology and Human Ecology of the Scientific and Technological Park of Biomedicine PhD-student of the Department of Medical Elementology;
E-mail: skalnyy-aa@rudn.ru; ORCID: 0000-0001-5310-3853; SPIN: 9069-0962
Tatiana V. Korobeinikova – Ph.D. (Tech.), Head of the Laboratory of Molecular Dietetics; Associate Professor of the Department of Medical Elementology
E-mail: tatcvetk@yandex.ru; ORCID: 0000-0002-1373-6354; SPIN: 7764-6486
Anna L. Mazaletskaya – Ph.D. (Psych.), Researcher, Laboratory of Ecobiomonitoring and Quality Control
E-mail: almaz_305@mail.ru; ORCID: 0000-0002-1108-5949; SPIN: 8963-3489
Ekaterina A. Flerova – Ph.D. (Biol.), Senior Researcher of the Laboratory of Ecobiomonitoring and Quality Control;
E-mail: katarinum@mail.ru; ORCID: 0000-0002-9745-6746; SPIN: 8116-7764
Andrei R. Grabeklis – Ph.D. (Biol.), Head of the Laboratory of Medical Elementology and Human Ecology at the Research Institute of Molecular and Cellular Medicine; Senior Lecturer at the Department of Medical Elementology
E-mail: andrewgrabeklis@gmail.com; ORCID: 0000-0003-4017-4139; SPIN: 9227-5941
Elena V. Rylina – Ph.D. (Pharm.), Associate Professor of the Department of Medical Elementology Medical Elementology
E-mail: edirector@drskalny.ru; ORCID: 0000-0002-9375-309X; SPIN: 4372-9977
Alexey A. Tinkov – Dr. Sc. (Med.), Leading Research Scientist of the Laboratory of Molecular Dietetics;
Senior Researcher of the Laboratory of Ecobiomonitoring and Quality Control3
E-mail: tinkov.a.a@gmail.com; ORCID: 0000-0003-0348-6192; SPIN: 3329-3442
Conflict of interest
The authors declare no obvious and potential conflicts of interest related to the publication of this article.
Funding
This study was performed with the support of the Russian Ministry of Science and Higher Education, Project No. FENZ-2023-0004