ABSTRACT. Speciation analysis (analysis of chemical forms of elements) is an important field in analytical chemistry, which makes it possible to determine not only the total content of an element, but also its specific chemical forms (types). This is especially important for understanding the bioavailability, toxicity, and environmental impact of the elements. This article discusses the most modern, applied and available methods for detection the forms of certain chemical elements. As a rule, two complementary methods are needed for speciation analysis of trace elements - separation and detection. The first ensures effective and reliable species separation, while the second ensures adequate detection and quantification. Progress in analytical tools and methodology makes it possible to identify and analyze the forms presented in a specific individual system.
KEYWORDS: speciation analysis, inductively coupled plasma mass spectrometry, atomic spectrometry, selenium,arsenic, mercury.
For citation: Lyapunovsky D.M. Separation methods for speciation analysis in biomedical research. Trace elemets in medicine. 2025;26(3):11−15. DOI: 10.19112/2413-6174-2025-26-3-11-15
Information about the author:
D.M. Lyapunovsky – Post-graduate Student, Research Intern,
Research Institute of Molecular and Cellular Medicine, Medical Institute;
Leading Analytical Chemist;
ORCID: 0009-0003-4863-1792