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Trace Elements in Medicine
International scientific and practical peer-reviewed journal
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METHODICAL ASSESSMENT OF QUALITY CONTROL OF TOXIC ELEMENTS IN URINE BY INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY

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Yu.N. Lobanova1,2, T.B. Korobeynikova1,3, E.P. Serebryansky2, G.D. Morozova4

1 Peoples Friendship University of Russia,
6, Mikluho-Maklaya str., Moscow, 117198, Russia

2 I.M. Sechenov First Moscow State Medical University
(Sechenov University), 8/2, Trubetskaya str., Moscow, Russia, 119991

3 Micronutrients Ltd.,
Moscow 13/8, Perevedenovsky str., Moscow, Russia, 105082

4 FSBI "Scientific and Clinical Center of Toxicology named after S.N. Golikov FMBA of Russia",
 1, Bekhtereva str., 192019, St. Petersburg, Russia


ABSTRACT. Quality control in modern laboratory practice includes the determination of metrological characteristics such as reproducibility, correctness and precision. This research deals with evaluation of the quality of determination of toxic elements in urine by inductively coupled plasma mass spectrometry was assessed according to GOST R 53133.2-2008. Measurement of chemical elements (Hg, As, Pb, Cd, Tl) in urine control materials by inductively coupled plasma mass spectrometry showed acceptable repeatability and precision. It has been established that the repeatability of the results is acceptable, since the coefficient of intra-series variation of the method does not exceed half of the maximum allowable value of the coefficient of total analytical variation. Thus, random and systematic errors were taken into account. Assessment within the laboratory quality control of the determination of toxic elements in urine by inductively coupled plasma mass spectrometry revealed the possibility of using this method in clinical diagnostic and scientific laboratories.

KEYWORDS: urine, mercury, arsenic, lead, cadmium, thallium, mass spectrometry, metrological characteristics.