Yu.N. Lobanova1,2, T.B. Korobeynikova1,3, E.P. Serebryansky2, G.D. Morozova4
Friendship University of Russia,
6, Mikluho-Maklaya str., Moscow, 117198, Russia
Sechenov First Moscow State Medical University
(Sechenov University), 8/2, Trubetskaya str., Moscow, Russia, 119991
3 Micronutrients Ltd.,
Moscow 13/8, Perevedenovsky str., Moscow, Russia, 105082
"Scientific and Clinical Center of Toxicology named after S.N. Golikov
FMBA of Russia",
1, Bekhtereva str., 192019, St. Petersburg, Russia
control in modern laboratory practice includes the determination of
metrological characteristics such as reproducibility, correctness and
precision. This research deals with evaluation of the quality of determination
of toxic elements in urine by inductively coupled plasma mass spectrometry was
assessed according to GOST R 53133.2-2008. Measurement of chemical elements (Hg, As, Pb, Cd,
Tl) in urine control materials by inductively coupled
plasma mass spectrometry showed acceptable repeatability and precision.
has been established that the repeatability of the results is acceptable, since
the coefficient of intra-series variation of the method does not exceed half of
the maximum allowable value of the coefficient of total analytical variation.
Thus, random and systematic errors were taken into account. Assessment within
the laboratory quality control of the determination of toxic elements in urine
by inductively coupled plasma mass spectrometry revealed the possibility of
using this method in clinical diagnostic and scientific laboratories.
KEYWORDS: urine, mercury, arsenic, lead, cadmium, thallium, mass spectrometry, metrological characteristics.