Trace Elements in Medicine (Moscow)
2021, 22(2): 36-42
ORIGINAL PAPERS

FEATURES OF THE ELEMENT STATUS OF THE BONE TISSUE OF THE TIMOUS BONE IN ACUTE AND CHRONIC PURULENT DISEASES OF THE MIDDLE EAR

A.I. Sinitskii¹, M.Y. Korkmazov¹, I.D. Dubinets¹, D.A. Uchaev², A.A. Shcherbakov³, O.L. Kolesnikov ¹

¹ South Urals State Medical University of the Ministry of Healthcare of the Russian Federation, Vorovsky street 64, 454092, Chelyabinsk, Russia
² Scientific and Educational Center “Nanotechnology” FSAEI HE “SUSU (NRU)”, Lenin Ave. 76, 454080, Chelyabinsk, Russia
³ Municipal Autonomous Healthcare Institution City Clinical Hospital № 6, Rumyantseva 28, 454017, Chelyabinsk, Russia

DOI: 10.19112/2413-6174-2021-22-4-36-42 

ABSTRACT. The content of essential and toxic chemical elements in patients with acute and chronic purulent otitis media who underwent reconstructive sanitation surgery on the middle ear cavity was studied. The study included 54 patients of working age (16-60 years old) with a verified diagnosis of acute purulent otitis media or chronic purulent otitis media and their complications that are subject to surgical treatment. The elemental composition of bone tissue of the temporal bone obtained intraoperatively was evaluated by X-ray fluorescence spectroscopy (Chelyabinsk). X-ray fluorescence analysis was performed on a Rigaku Supermini wave dispersion X-ray spectrometer (RIGAKU Corp. Japan). The data were processed by descriptive statistics and presented as a median and a range between quartiles with an estimate of the reliability of intergroup differences by the Mann-Whitney U-test.An analysis of the results allows us to conclude that there are significant changes in the elemental composition of bone tissue, depending on the timing of the development of diseases, relapses and complications. The revealed imbalance of elements is both an inducer and a consequence of pathomorphological irreversible transformation of bone tissue, and on this basis, it can serve as an indicator for the progressive course of purulent otitis media in both acute and chronic inflammation.

KEYWORDS: elementalcomposition, temporalbone, purulentotitismedia, complications.